Adeno-Associated Virus-Mediated Gene Transfer into Taste CellsIn Vivo
نویسندگان
چکیده
منابع مشابه
Kinetics of recombinant adeno-associated virus-mediated gene transfer.
Recombinant adeno-associated virus (rAAV) vectors have been shown to be useful for efficient gene delivery to a variety of dividing and nondividing cells. Mechanisms responsible for the long-term, persistent expression of the rAAV transgene are not well understood. In this study we investigated the kinetics of rAAV-mediated human factor IX (hFIX) gene transfer into human primary myoblasts and m...
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Recombinant adeno-associated viruses (rAAV) containing only the inverted terminal repeats (ITR) from the wild-type virus are capable of stable integration into the host cell genome, and expression of inserted genes in cultured cells. We have now defined the ability of rAAV to introduce genes into primary hematopoietic progenitors. A vector was constructed containing the coding sequences for bet...
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Foreign genes can be transferred into taste cells via adenoviral vectors. The present study was undertaken to characterize the subpopulation of taste cells that are susceptible to adenovirus infection and to determine whether another viral vector, derived from herpes simplex 1 (HSV-1), infects the same subpopulation of taste cells. Using an adenovirus containing the gene for enhanced green fluo...
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Adeno-associated virus (AAV) is currently being used in several human gene therapy trials, including one targeting hemophilia B and another targeting cystic fibrosis, and to date has demonstrated persistent expression without inflammation of the target tissue. Some of the unique features that have distinguished AAV from other gene therapy vectors include (i) its ability to transduce both dividi...
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ژورنال
عنوان ژورنال: Chemical Senses
سال: 2016
ISSN: 0379-864X,1464-3553
DOI: 10.1093/chemse/bjw101